Aminooxyacetic acid (AOA)(AOAA)

Here we look at the claims for aminooxyacetic acid (AOA)(AOAA).

Version: 2.1 Last updated: April 2023 To be reviewed: November 2025

Treatment details

Illustration of bottle of pills.





Evidence of harm



No or limited evidence that it is effective



The makers claim

That aminooxyacetic acid may reduce central auditory hyperactivity that may be related to tinnitus[1].

What is the treatment?

Aminooxyacetic acid is taken in pill or capsule form. In studies, the dosage was 50 or 75mg, four times a day[2].

What are the downsides of this treatment?

In trials, about 70% of patients reported side effects, including nausea and dizziness[2].

Has there been research into this treatment?

Yes[2] [3]

What does the research say?

Although aminooxyacetic acid reduces the severity of tinnitus in about 20% of patients, the incidence of side effects makes the drug unacceptable for clinical use[2].

Few people are helped by aminooxyacetic acid, and many more experience side effects. It is not recommended for use.

Tinnitus UK

All online references accessed 1 November 2022 unless noted.

1. Tunkel DE, Bauer CA, Sun GH, et al. Clinical Practice Guideline: Tinnitus. Otolaryngology–Head and Neck Surgery. (2014) 151(2_suppl): S1-S40.

2. Guth PS, Risey J, Briner W, Blair P, Reed HT, Bryant G, Norris C, Housley G, Miller R. Evaluation of aminooxyacetic acid as a palliative in tinnitus. Annals of Otology, Rhinology & Laryngology. (1990) Jan;99(1):74-9. doi:
10.1177/000348949009900113. PMID: 1688487.

3. Reed HT, Meltzer J, Crews P, Norris CH, Quine DB. Guth PS. Amino oxyacetic acid as a palliative in tinnitus. Archives of
Otolaryngology. (1985) 111: 803-805