Synapse XT

Here we look at the claims for Synapse XT.

Version: 2.0 Last updated: April 2023 To be reviewed: October 2025

Treatment details

Illustration of a bottle with a star on the front of it.


Branded dietary supplement



Some potential for harm



No or limited evidence that it is effective



The makers claim

Synapse XT will “prevent the buzzing sound in your ears”[1].

What is the treatment?

Synapse XT is a capsule. The suggested use is 2 capsules which you take once a day with water.

The ingredients of Synapse XT are listed as Hibiscus; hawthorn berry; garlic; Vitamin B; green tea; juniper berry, Vitamin C1.

An image of the label, however, lists the ingredients as Riboflavin (Vitamin B2); Vitamin B6; folate (Vitamin B9); magnesium citrate; potassium citrate; hibiscus; garlic; hawthorn berry; rosemary[1].

There are claims that “Synapse XT supplement is extraordinarily formulated with around 233 unique and effective ingredients”2 but we have been unable to find out any more information.

What are the downsides of this treatment?

Potential side effects, allergic reactions and drug interactions from constituents.[3-15]

Cost – this supplement currently is on sale for $69 for one month’s supply excluding shipping and taxes.[1]

Has there been research into this treatment?

There have been no papers published on Synapse XT as a supplement, but there have been a number published on its component parts.

What does the research say?

With the exception of one small trial of a magnesium supplement, which showed positive results[16], there is no evidence that any of the known components of this supplement are effective for treating tinnitus.[3-15]

Although some of the components are thought of as safe, some may be harmful including Vitamin B6 (if taken for prolonged periods)[7], green tea in large doses[9] and potassium[14] (if taken in large doses).

Although independent evidence is limited, what there is does not show that the components of this supplement are effective for tinnitus and that there may be risks involved in taking this supplement. We would suggest you talk to your GP before taking any new medication or supplement.

“Dietary supplements should not be recommended to treat tinnitus.”[17]

Tinnitus UK


There appears to be a lot of similarity between the marketing of this product and other products such as Sonus Complete and Tinnitus 911 – please see the relevant information sheets for details.

All online references accessed 12 October 2022 unless noted.


2. Felipe, A. Synapse XT Review– Is It A Scam Or True Supplement For Brain Health? Available from

3. The Drugsite Trust. Hibiscus.

4. The Drugsite Trust. Hawthorn.

5. The Drugsite Trust. Garlic.

6. US National Library of Medicine.

7. National Institutes of Health Office of Dietary Supplements. Vitamin B6.

8. National Institutes of Health Office of Dietary Supplements. Folate.

9. Hu J, Webster D et al. The Safety of Green Tea and Green Tea Extract Consumption in Adults – Results of a Systematic Review. Regulatory Toxicology and Pharmacology.(2018) 95. 412-433.
DOI: 10.1016/j.yrtph.2018.03.019

10. The Drugsite Trust. Green tea.

11. The Drugsite Trust. Juniper.

12. National Institutes of Health Office of
Dietary Supplements. Vitamin C.

13. National Institutes of Health Office of
Dietary Supplements. Magnesium.

14. WebMD LLC. Potassium – Uses,
Side Effects, and More.

15. The Drugsite Trust. Rosemary.

16. Patel, A. Phase Two Study Examining Magnesium Dependent Tinnitus. (2012). Thesis, The University of Arizona.

17. Coelho C, Tyler R et al. Survey on the Effectiveness of Dietary Supplements to Treat Tinnitus. American Journal of Audiology. (2016) 25(3): 184-205