Lamotrigine (Lamictal)

Here we look at the claims for Lamotrigine (Lamictal).

Version: 1.0 Last updated: April 2023 To be reviewed: November 2025

Treatment details

Illustration of bottle of pills.





Some potential for harm



Evidence that it is not effective



Claims for treatment

That anticonvulsants potentially reduce central auditory hyperactivity that may be related to tinnitus[1].

What is the treatment?

Lamotrigine is taken in tablet form.

What are the downsides of this treatment?

Common side effects from clinical trials included nausea, dizziness, headache, tiredness[2].

Lamotrigine can also trigger skin rashes[3].

Has there been research into this treatment?

One study has been conducted[4].

What does the research say?

Although a small scale study, lamotrigine was not effective as a treatment for tinnitus[4].

There is no evidence to show that anticonvulsants have a large positive effect in the treatment of tinnitus[2].

There is no evidence to show that lamotrigine has an impact on tinnitus.

Use of anticonvulsants for epilepsy may result in tinnitus and other auditory dysfunctions[5].

Tinnitus UK


Yes, provided study is of high quality.

All online references accessed 9 November 2022 unless noted.

1. Tunkel DE, Bauer CA, Sun GH, et al. Clinical Practice Guideline: Tinnitus. Otolaryngology–Head and Neck Surgery. (2014) 151(2_suppl): S1-S40.

2. Hoekstra CEL, Rynja SP, van Zanten GA, Rovers MM. Anticonvulsants for tinnitus. Cochrane Database of Systematic Reviews (2011) Issue 7. Art. No.: CD007960. DOI: 10.1002/14651858.

3. NHS. About lamotrigine.

4. Simpson JJ, Gilbert AM, Weiner GM, Davies WW. The assessment of lamotrigine, an antiepileptic drug, in the treatment of tinnitus. American Journal of Otology (1999) 20:627-31.

5. Hamed SA. The auditory and vestibular toxicities induced by antiepileptic drugs, Expert Opinion on Drug Safety,(2017) 16:11, 1281-1294, DOI: