MemoVigor2
MemoVigor2 is a tablet taken once a day [1].
Treatment details
Type
Branded dietary supplement
Safety
Evidence of harm
Efficacy
No or limited evidence that it is effective
Recommended?
No
Claims for treatment
The makers claim that “it contributes to the normal functioning of the nervous system” [1] and make no claims as to its use as a tinnitus treatment. However, these claims appear on other retail sites [2]
What is the treatment?
MemoVigor2 is a tablet taken once a day [1]. The ingredients of MemoVigor [2] are listed as Acetyl-L-Carnitine, Vitamin C, Vitamin B1, Vitamin B12, Vitamin B6, Vitamin E, Glutamic Acid, Myrtillo extract (bilberry), Potassium, Magnesium, Selenium, Ginkgo Leaf, Phosphatidylethanolamine, Phosphatidylinositol, Phosphatidylcholine, Phosphatidylserine. [1]
What are the downsides of this treatment?
Potential side effects, allergic reactions and drug interactions from the constituents, especially Ginkgo biloba [3-12, 14 16] . Magnesium and Acetyl-LCarnitine can cause minor but unpleasant side effects [12,3]. Vitamin B6, Vitamin E and potassium can be harmful in large doses [7,8,11]. High doses or long-term use of selenium can lead to serious medical problems or death [14].
Cost – the tablets retail for around €23 for 20 tablets. This excludes shipping and customs charges [2].
Has there been research into this treatment?
There has been one paper published on MemoVigor2 as a supplement, but it was not a fully independent study [15]. There are a number of papers on the effects of its component parts.
What does the research say?
The limited evidence does not demonstrate that Ginkgo biloba is effective for tinnitus when this is the primary complaint. [17] It does not reduce the intensity of tinnitus or improve quality of life. [18]
There is limited evidence that vitamin B12 [6] and magnesium [13] may help tinnitus in people who are deficient in these elements.
There is no evidence that any of the other components of this supplement are effective as a tinnitus treatment [3-5,7-14].
Although independent evidence is limited, what there is does not show that the components of this supplement are effective for tinnitus. The
potential side effects may cause serious harm. We would suggest you talk to your GP before taking any new medication or supplement.
“Dietary supplements should not be recommended to treat tinnitus” [19]
Comments
Practice guidelines do not recommend the use of Ginkgo biloba as a treatment for tinnitus [20 21].
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Give what you canAll online references accessed 13 March 2024 unless noted.
1. Bionat. Bionat MemoVigor2 for memory 20 tablets https://www.bionat.gr/en/memovigor2.html
2. Best Pharmacy. Bionat Memovigor 2 900mg 20 Tabs For Vertigo, Tinnitus, Enhances Memory. https://bestpharmacy.gr/en/bionat-memovigor-2-900mg-20-tabs.html
3. National Institutes of Health Office of Dietary Supplements. Carnitine. www.ods.od.nih.gov/factsheets/Carnitine-HealthProfessional/
4. National Institutes of Health Office of Dietary Supplements. Vitamin C. www.ods.od.nih.gov/factsheets/VitaminCConsumer/
5. National Institutes of Health Office of Dietary Supplements. Thiamin. https://ods.od.nih.gov/factsheets/thiamin-Consumer/#h7
6. National Institutes of Health Office of Dietary Supplements. Vitamin B12. www.ods.od.nih.gov/factsheets/VitaminB12-Consumer/
7. National Institutes of Health Office of Dietary Supplements. Vitamin B6. www.ods.od.nih.gov/factsheets/VitaminB6-Consumer/
8. National Institutes of Health Office of Dietary Supplements. Vitamin E. https://ods.od.nih.gov/factsheets/VitaminEHealthProfessional/
9. University of Rochester Medical Center. Health Encyclopedia: Glutamic Acid. urmc.
rochester.edu/encyclopedia/content.aspx?contenttypeid=19&contentid=GlutamicAcid
10. Drugsite Trust. Bilberry. Available from https://www.drugs.com/cdi/ginkgobiloba.html
11. National Institutes of Health Office of Dietary Supplements. Potassium. www.ods.od.nih.gov/factsheets/Potassium-Consumer/
12. National Institutes of Health Office of Dietary Supplements. Magnesium. www.ods.od.nih.gov/factsheets/magnesium-Consumer/
13. Cevette MJ, Barrs DM, Patel A, et al. Phase 2 study examining magnesium dependent
tinnitus. International Tinnitus Journal. (2011);16(2):168-73
14. National Institutes of Health Office of Dietary Supplements. Selenium. https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/#h17
15. Balatsouras DG, Papitsi I, Koukoutis G, Katotomichelakis M. The effect of MemoVigor2 on recent-onset idiopathic tinnitus: a randomized double-blind placebo-controlled clinical trial. Frontiers in Pharmacology. (2024); Volume 15. https://doi.org/10.3389/ fphar.2024.1252343
16. Drugsite Trust. Ginkgo biloba. Available from https://www.drugs.com/cdi/ginkgo-biloba.html
17. Hilton MP, Zimmermann EF, Hunt WT. Ginkgo biloba for tinnitus. Cochrane Database of Systematic Reviews (2013), Issue 3. Art. No.: CD003852. doi: 10.1002/14651858.CD003852.pub3.
18. Kramer F, Ortigoza Á. Ginkgo biloba for the treatment of tinnitus. Medwave. (2018) Oct 17;18(6):e7295. English, Spanish. doi: 10.5867/medwave.2018.06.7294. Erratum in: Medwave. (2018) Nov 13;18(7):e7337.
19. Coelho C, Tyler R et al. Survey on the Effectiveness of Dietary Supplements to Treat Tinnitus. American Journal of Audiology. (2016) 25(3): 184-205
20. British Society of Audiology. Practice Guidance – Tinnitus in Adults. (2021) Available from: www.thebsa.org.uk/resources/practice-guidance-tinnitus-inadults/
21. Tunkel DE, Bauer CA, Sun GH, et al. Clinical Practice Guideline: Tinnitus. Otolaryngology–Head and Neck Surgery. (2014);151(2_suppl): S1-S40. doi:10.1177/0194599814545325